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1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP)-promoted regiospecific 1,6-hydroarylation of para-quinone methides with N-heteroarenes: Synthesis of unsymmetrical triarylmethanes.
- Source :
-
Tetrahedron . May2024, Vol. 158, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- In this work, a recyclable and highly regioselective 1,6-hydroarylation of para -quinone methides (p -QMs) with N -heteroarenes has been developed under mild conditions. 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as a solvent plays a significant role in this transformation to achieve a wide assortment of unsymmetrical triarylmethanes with high yields and excellent regioselectivity. This novel reaction is featured a very broad substrate scope and outstanding functional group tolerance and could also be scaled-up. Moreover, this Friedel-Crafts alkylation pathway is further supported by replacing HFIP with trifluoroethanol (TFE) in the control reactions. A highly regioselective 1,6-hydroarylation of para -quinone methides (p -QMs) with N -heteroarenes has been developed under mild conditions. 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) as a solvent plays a significant role in this transformation to achieve a wide assortment of unsymmetrical triarylmethanes with high yields and excellent regioselectivity. Moreover, this transformation can be easily extended to a gram scale-synthesis level. [Display omitted] [ABSTRACT FROM AUTHOR]
- Subjects :
- *QUINONE compounds
*FUNCTIONAL groups
*ALKYLATION
*QUINONE
*SOLVENTS
Subjects
Details
- Language :
- English
- ISSN :
- 00404020
- Volume :
- 158
- Database :
- Academic Search Index
- Journal :
- Tetrahedron
- Publication Type :
- Academic Journal
- Accession number :
- 177222016
- Full Text :
- https://doi.org/10.1016/j.tet.2024.133982