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Human antigen R: Exploring its inflammatory response impact and significance in cardiometabolic disorders.

Authors :
Abdelsam, Shahenda Salah
Ghanem, Sarah Khalaf
Zahid, Muhammad Ammar
Abunada, Hanan H.
Bader, Loulia
Raïq, Hicham
Khan, Abbas
Parray, Aijaz
Djouhri, Laiche
Agouni, Abdelali
Source :
Journal of Cellular Physiology. May2024, Vol. 239 Issue 5, p1-15. 15p.
Publication Year :
2024

Abstract

RNA‐binding proteins (RBPs) play a crucial role in the regulation of posttranscriptional RNA networks, which can undergo dysregulation in many pathological conditions. Human antigen R (HuR) is a highly researched RBP that plays a crucial role as a posttranscriptional regulator. HuR plays a crucial role in the amplification of inflammatory signals by stabilizing the messenger RNA of diverse inflammatory mediators and key molecular players. The noteworthy correlations between HuR and its target molecules, coupled with the remarkable impacts reported on the pathogenesis and advancement of multiple diseases, position HuR as a promising candidate for therapeutic intervention in diverse inflammatory conditions. This review article examines the significance of HuR as a member of the RBP family, its regulatory mechanisms, and its implications in the pathophysiology of inflammation and cardiometabolic illnesses. Our objective is to illuminate potential directions for future research and drug development by conducting a comprehensive analysis of the existing body of research on HuR. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00219541
Volume :
239
Issue :
5
Database :
Academic Search Index
Journal :
Journal of Cellular Physiology
Publication Type :
Academic Journal
Accession number :
177219879
Full Text :
https://doi.org/10.1002/jcp.31229