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Protein‐Integrated Hydrogen‐Bonded Organic Frameworks: Chemistry and Biomedical Applications.

Protein‐Integrated Hydrogen‐Bonded Organic Frameworks: Chemistry and Biomedical Applications.

Authors :
Li, Lijuan
Ma, Tianyu
Wang, Ming
Source :
Angewandte Chemie International Edition. 5/21/2024, Vol. 63 Issue 21, p1-690. 690p.
Publication Year :
2024

Abstract

Hydrogen‐bonded organic frameworks (HOFs) are porous nanomaterials that offer exceptional biocompatibility and versatility for integrating proteins for biomedical applications. This minireview concisely discusses recent advancements in the chemistry and functionality of protein‐HOF interfaces. It particularly focuses on strategic methodologies, such as the careful selection of building blocks and the genetic engineering of proteins, to facilitate protein‐HOF interactions. We examine the role of enzyme encapsulation within HOFs, highlighting its capability to preserve enzyme function, a crucial aspect for applications in biosensing and disease diagnosis. Moreover, we discuss the emerging utility of nanoscale HOFs for intracellular protein delivery, illustrating their applicability as nanoreactors for intracellular catalysis and neuroprotective biorthogonal catalysis within cellular compartments. We highlight the significant advancement of designing biodegradable HOFs tailored for cytosolic protein delivery, underscoring their promising application in targeted cancer therapies. Finally, we provide a perspective viewpoint on the design of biocompatible protein‐HOF assemblies, underlining their promising prospects in drug delivery, disease diagnosis, and broader biomedical applications. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14337851
Volume :
63
Issue :
21
Database :
Academic Search Index
Journal :
Angewandte Chemie International Edition
Publication Type :
Academic Journal
Accession number :
177192362
Full Text :
https://doi.org/10.1002/anie.202400926