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Oral lesions with immunohistochemical evidence of Sars‐CoV‐2 in swab‐negative post‐COVID syndrome.

Authors :
Limongelli, Luisa
Favia, Gianfranco
Maiorano, Eugenio
D'Amati, Antonio
Pispero, Alberto
Ingravallo, Giuseppe
Barile, Giuseppe
Tempesta, Angela
Dell'Olio, Fabio
Siciliani, Rosaria Arianna
Capodiferro, Saverio
Source :
Oral Diseases. Apr2024, Vol. 30 Issue 3, p1264-1272. 9p.
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Objectives: Growing evidence exists about post‐COVID condition/syndrome as sequelae of Sars‐CoV‐2 infection in healed patients, possibly involving the lungs, brain, kidney, cardiovascular and neuromuscular system, as well the persistency of taste dysfunction. Such symptoms develop during or after infection and continue for more than 12 weeks with pathogenesis related to virus persistency but variable by organs or systems. Materials and Methods: We recently observed six patients recovered from COVID‐19 and with negative RT‐PCR testing, showing oral mucosa lesions (mainly ulcers) overlapping those occurring in the acute phase, persisting up to 20 days and thus needing a biopsy with histological investigation and spike protein evaluation by immunohistochemistry. Results: We found epithelial ulceration, inflammatory infiltrate, vessels with increased diameter and flattened endothelium but no thrombi formation; also, we found a weak epithelial SARS‐CoV‐2 positivity limited to the basal/spinosum layers, progressively decreasing toward the periphery, and the intraepithelial lymphomonocytes, endothelium, and perivascular pericytes too. Conclusions: Our findings provide evidence that SARS‐CoV‐2 can persist, as for other organs/systems, also in the oral epithelium/mucosa after the acute phase and can be responsible for lesions, although by a pathogenetic mechanism that should be better defined but certainly referable as the oral mucosa counterpart of post‐COVID syndrome. [ABSTRACT FROM AUTHOR]


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Academic Search Index
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Oral Diseases
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Academic Journal
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