Onychomatricoma is not a subtype of superficial acral fibromyxoma: Can immunohistochemistry help in the differential diagnosis?

The article titled "Onychomatricoma is not a subtype of superficial acral fibromyxoma: Can immunohistochemistry help in the differential diagnosis?" discusses the debate surrounding the classification of onychomatricoma (OM) and superficial acral fibromyxoma (SAFM) as distinct tumors. The authors argue that OM should be recognized as a fibrous neoplasm rather than a fibroepithelial neoplasm, based on their shared immunohistochemical profile and loss of RB1. However, the overall consensus is that OM and SAFM have clinical and histopathologic features that allow for easy differentiation. The article provides distinguishing features between the two tumors and acknowledges that the diagnosis of OM can be challenging in the absence of clinical information or when the nail plate is not submitted for examination. [Extracted from the article]