Spirocyclopentene Oxindoles through LiHMDS Based Allylation and Ring Closing Metathesis.

This article discusses a new method for synthesizing spirocyclopentene oxindoles, which are found in natural products and biologically active molecules. The authors describe the synthesis process using lithium bis(trimethylsilyl)amide (LiHMDS) and ring closing metathesis. The yields of the desired compounds ranged from 55% to 88%, with some side products observed in certain cases. The authors provide detailed physical and spectroscopic data for each compound synthesized. The article acknowledges the institutions that provided resources and support for the research. [Extracted from the article]