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Dietary phenolic compounds as promising therapeutic agents for diabetes and its complications: A comprehensive review.

Authors :
Aryal, Dipa
Joshi, Soniya
Thapa, Nabin Kumar
Chaudhary, Pratiksha
Basaula, Sirjana
Joshi, Usha
Bhandari, Damodar
Rogers, Hannah M.
Bhattarai, Salyan
Sharma, Khaga Raj
Regmi, Bishnu P.
Parajuli, Niranjan
Source :
Food Science & Nutrition. May2024, Vol. 12 Issue 5, p3025-3045. 21p.
Publication Year :
2024

Abstract

In the middle of an ever‐changing landscape of diabetes care, precision medicine, and lifestyle therapies are becoming increasingly important. Dietary polyphenols are like hidden allies found in our everyday meals. These biomolecules, found commonly in fruits, vegetables, and various plant‐based sources, hold revolutionary potential within their molecular structure in the way we approach diabetes and its intimidating consequences. There are currently numerous types of diabetes medications, but they are not appropriate for all patients due to limitations in dosages, side effects, drug resistance, a lack of efficacy, and ethnicity. Currently, there has been increased interest in practicing herbal remedies to manage diabetes and its related complications. This article aims to summarize the potential of dietary polyphenols as a foundation in the treatment of diabetes and its associated consequences. We found that most polyphenols inhibit enzymes linked to diabetes. This review outlines the potential benefits of selected molecules, including kaempferol, catechins, rosmarinic acid, apigenin, chlorogenic acid, and caffeic acid, in managing diabetes mellitus as these compounds have exhibited promising results in in vitro, in vivo, in silico, and some preclinical trials study. This encompassing exploration reveals the multifaceted impact of polyphenols not only in mitigating diabetes but also in addressing associated conditions like inflammation, obesity, and even cancer. Their mechanisms involve antioxidant functions, immune modulation, and proinflammatory enzyme regulation. Furthermore, these molecules exhibit anti‐tumor activities, influence cellular pathways, and activate AMPK pathways, offering a less toxic, cost‐effective, and sustainable approach to addressing diabetes and its complications. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20487177
Volume :
12
Issue :
5
Database :
Academic Search Index
Journal :
Food Science & Nutrition
Publication Type :
Academic Journal
Accession number :
177114160
Full Text :
https://doi.org/10.1002/fsn3.3983