Ferroptosis: An important mechanism of disease mediated by the gut-liver-brain axis.

As a unique iron-dependent non-apoptotic cell death, Ferroptosis is involved in the pathogenesis and development of many human diseases and has become a research hotspot in recent years. However, the regulatory role of ferroptosis in the gut-liver-brain axis has not been elucidated. This paper summarizes the regulatory role of ferroptosis and provides theoretical basis for related research. We searched PubMed, CNKI and Wed of Science databases on ferroptosis mediated gut-liver-brain axis diseases, summarized the regulatory role of ferroptosis on organ axis, and explained the adverse effects of related regulatory effects on various diseases. According to our summary, the main way in which ferroptosis mediates the gut-liver-brain axis is oxidative stress, and the key cross-talk of ferroptosis affecting signaling pathway network is Nrf2/HO-1. However, there were no specific marker between different organ axes mediate by ferroptosis. Our study illustrates the main ways and key cross-talk of ferroptosis mediating the gut-liver-brain axis, providing a basis for future research. [Display omitted] • Clarifing the regulation and physiopathology of ferroptosis on gut-liver-brain axis. • Clarifing ferroptosis mediating the gut-liver-brain axis is oxidative stress. • Integrating signaling pathways of gut-liver-brain axis mediating ferroptosis. • The key cross-talk of ferroptosis affecting signaling pathway network is Nrf2/HO-1. • There was no differential marker in different ferroptosis-mediated organ axis. [ABSTRACT FROM AUTHOR]