血清 LRG1, GRP78 与急诊脓毒症患者继发急性肺损伤的关系研究.

Objective: To investigate the relationship between serum leucine-rich alpha-2 glycoprotein 1 (LRG1), glucose-regulated protein 78 (GRP78) and secondary acute lung injury (ALI) in patients with emergency sepsis. Methods: 155 patients with emergency sepsis who were treated in the emergency intensive care unit (EICU) of our hospital from January 2021 to October 2022 were retrospectively selected as observation group, patients were divided into ALI group (43 cases) and non-ALI group (112 cases) according to whether secondary ALI occurred, and 100 healthy subjects in our hospital during the same period were selected as control group. The levels of serum LRG1 and GRP78 were detected by enzyme-linked immunosorbent assay kit. The influencing factors of secondary ALI in patients with emergency sepsis were analyzed by univariate and multivariate logistic regression. The predictive value of serum LRG1 and GRP78 levels for secondary ALI in patients with emergency sepsis were analyzed by receiver operating characteristic (ROC) curve was used to analyze. Results: Compared with control group, the levels of serum LRG1 and GRP78 in observation group were increased (P<0.05). Univariate analysis showed that, ALI secondary to emergency sepsis was related to sepsis grade, EICU time, mechanical ventilation, sepsis-related organ failure assessment (SOFA) score, blood lactic acid, LRG1 and GRP78 (P<0.05). Multivariate logistic regression analysis showed that, septic shock, prolonged EICU time and increased SOFO score, blood lactic acid, LRG1 and GRP78 were independent risk factors for secondary ALI in patients with emergency sepsis (P<0.05). ROC curve analysis showed that, the area under the curve (AUC) of serum LRG1 and GRP78 levels alone and in combination in predicting ALI secondary to emergency sepsis were 0.790, 0.782 and 0.884 respectively, and the AUC of combined prediction was the largest (P<0.05). Conclusion: The increase of serum LRG1 and GRP78 levels in patients with emergency sepsis is closely relate to secondary ALI, and the combination of serum LRG1 and GRP78 levels has a higher value in predicting secondary ALI in patients with emergency sepsis. [ABSTRACT FROM AUTHOR]