慢性阻塞性肺疾病不同表型患者 CAT 评分与肺功能 及预后的相关性分析.

To investigate the correlation between COPD assessment test (CAT) scores and lung function as well asprognos is of patients of chronic obstructive pulmonary disease (COPD) with different phenotypes. A total of 361 patients with COPD were involved in this study. Their clinical data, CAT scores, lung function test results, extrapulmonary comorbidities and intrapulmonary complications were collected. Then, these patients were divided into emphysema group (n=200) and the bronchitis group(n=161) according to their clinical phenotype. The correlation was analyzed between CAT scores, lung function, and prognosis in emphysema group and bronchitis group. The CAT score of the emphysema group was higher than that of the bronchitis group(P<0.05). The percentage of forced expiratory volume in one second (FEV1 ) of the expected value (FEV1% ) and FEV1/forced vital capacity (FVC) were lower than those in the bronchitis group (P<0.05). The inspiratory capacity/total lung capacity (IC/TLC) was lower than that of the bronchitis group, and the residual volume/total lung capacity (RV/TLC) was higher than that of the bronchitis group (P<0.05). The incidence rates of pulmonary interstitial disease and pulmonary hypertension in the emphysema group were higher than those in the bronchitis group (P<0.05). The CAT scores of both groups were negatively correlated with FEV1%, FEV1/FVC and IC/TLC (P<0.05),and positively correlated with RV/TLC (P<0.05). The correlation of emphysema parameters was higher (P<0.05). There were statistically significant differences in the incidence rates of pulmonary interstitial disease and pulmonary hypertension between patients with different CAT scores in emphysema group (P<0.05). There was a statistically significant difference in the incidence of pulmonary hypertension between patients with different CAT scores in the bronchitis group (P<0.05). As the CAT score increased, the incidence rates of pulmonary interstitial disease and pulmonary hypertension in the emphysema group increased, and the incidence rate of pulmonary hypertension in the bronchitis group increased. The CAT score of patients with emphysema phenotype of COPD is higher than those with bronchitis phenotype. Besides, lung function decline is more obvious in the former group, showing characteristics of pulmonary hyperventilation and restricted airflow. The former are more likely to have pulmonary fibrosis and pulmonary arterial hypertension, which is closely related to changes in CAT scores. [ABSTRACT FROM AUTHOR]