黄体酮对子宫内膜异位症在位内膜预处理与 IVF 治疗结局关系.

To investigate whether the treatment outcome of IVF can be improved by progesterone pretreatment of endometriosis. 168 cases with male factors and ovarian endometriosis cysts were divided into two groups: (1) experimental group: 12 days of natural cycle menstruation before IVF dystogesterone, 30 mg/day, 14 days, 3 months; (2) Control group: no intervention before IVF. Blood CA125 was measured before IVF, ovulation was induced by long luteal phase program, and CA125 was measured again one week after ovulation (pituitary hypo regulation day), and the endometrium was taken for ER, PR, HOXA-10 mrna detection and pathological examination. Endometrial thickness, morphology and blood flow were measured by HCG daily. Clinical data and outcomes were compared. The embryo implantation rate and clinical pregnancy rate were higher in the experimental group than in the control group (P<0.05); The endometrium was thicker in the control group than in the experimental group on HCG day. The ratio of endometrial type A blood flow in the experimental group was higher than that in the control group (P<0.05). The endometrial ratio of type A in the experimental group was higher than that in the control group, but there was no difference (P>0.05); CA125 was higher than the reference value in both groups before IVF, but there was no difference (P>0.05). The CA125 was lower in the experimental group than in the control group when the pituitary gland was retested on the day of pituitary downregulation, and lower in the experimental group than before the intervention; the expression of ER, PR and HOXA-10 mRNA in the endometrium was higher in the experimental group than in the control group, and the ratio of endometrium in the secretory phase was higher in the experimental group than in the control group(P<0.05); The pain scores of all symptoms were improved in both groups after treatment than before treatment, and the experimental group was better than the After treatment, the pain scores of both groups improved compared with those before treatment, and the experimental group was better than the control group(P<0.05). In IVF treatment of ovarian endometriosis cysts, preconditioning the endometrium with progesterone can reduce blood CA125, facilitate the transformation of endometrial tissue types, reduce endometrial thickness, increase endometrial blood flow, increase endometrial ER, PR, HOXA-10 mRNA expression, and improve endometrial receptivity, relieve symptoms and pain, Improve the clinical pregnancy rate. [ABSTRACT FROM AUTHOR]