اثر ملاتونین و تیزانیدین بر پارامترهای همودینامیک و اضطراب در بیماران تحت عمل جراحی کاتاراکت یک مطالعه کارآزمایی بالینی تصادفی شده دوسویه کور.

Introduction: Cataract is one of the most common diseases in the world and the most common cause of vision loss and blindness in the world. Stability of hemodynamic symptoms is one of the most important factors during cataract surgery. Therefore, the aim of this study is to investigate the effect of melatonin and tizanidine on hemodynamic parameters and anxiety in patients undergoing cataract surgery. Materials & Methods: This prospective clinical trial study was conducted on 90 patient's candidates for cataract surgery. Patients into three equal groups; Melatonin, tizanidine and placebo were divided. Hemodynamic parameters were recorded at baseline and every 5 minutes during surgery. After the operation was completed and the patients were transferred to the recovery room, postoperative anxiety in the recovery room and 24 hours after the operation (calling the patient) was checked by means of RASS tools. Results: There was no difference in the variables of age, sex, weight between the studied groups. Heart rate, diastolic and systolic blood pressure decreased over time in all three groups. Diastolic blood pressure in the 10th minute of surgery (late surgery) in the tizanidine group was significantly lower than the control group (P<0.05). Tukey's post hoc test showed that in the recovery room, the level of anxiety in people who received melatonin or tizanidine was significantly lower than the control group (P<0.05). There was no difference between the anxiety levels of the melatonin group and the tizanidine group (P=0.904). Conclusion: The results of this study showed that melatonin and tizanidine can reduce the anxiety of patients in the acute phase after surgery. Since tizanidine may lower blood pressure, melatonin prodrug seems to be a better option for reducing pain and anxiety in patients undergoing cataract surgery. [ABSTRACT FROM AUTHOR]