Tailored therapy for early Barrett's lesions.

Discusses recent advances in endoscopy for the diagnosis of adenocarcinoma arising on a background of Barrett's change. Increased potential of Barrett's esophagus for malignant degeneration, especially when the columnar epithelium demonstrates specialized intestinal metaplasia; Use of endoscopic mucosal resection (EMR) for safe removal of relatively large focal lesions in Barrett's esophagus; Importance of EMR as a therapeutic option in selected patients with early Barrett's cancer.