Assessment of risk-adjusted mortality ratio (RAMR) in bloodstream infections using all-patient refined diagnosis-related groups (APR-DRGs).

Objectives To calculate a risk-adjusted mortality ratio (RAMR) for bloodstream infections (BSIs) using all-patient refined diagnosis-related groups (APR-DRGs) and compare it with the crude mortality rate (CMR). Methods Retrospective observational study of prevalent BSI at our institution from January 2019 to December 2022. In-hospital mortality was adjusted with a binary logistic regression model adjusting for sex, age, admission type and mortality risk for the hospitalization episode according to the four severity levels of APR DRGs. The RAMR was calculated as the ratio of observed to expected in-hospital mortality, and the CMR was calculated as the proportion of deaths among all bacteraemia episodes. Results Of 2939 BSIs, 2541 were included: Escherichia coli (n  = 1310), Klebsiella pneumoniae (n  = 428), Pseudomonas aeruginosa (n  = 209), Staphylococcus aureus (n  = 498) and candidaemia (n  = 96). A total of 436 (17.2%) patients died during hospitalization and 279 died within the first 14 days after the onset of BSI. Throughout the period, all BSI cases had a mortality rate above the expected adjusted mortality (RAMR value greater than 1), except for Escherichia coli (1.03; 95% CI 0.86–1.21). The highest overall RAMR values were observed for P. aeruginosa , Candida and S. aureus with 2.06 (95% CI 1.57–2.62), 1.99 (95% CI 1.3–2.81) and 1.8 (95% CI 1.47–2.16), respectively. The temporal evolution of CMR may differ from RAMR, especially in E. coli , where it was reversed. Conclusions RAMR showed higher than expected mortality for all BSIs studied except E. coli and provides complementary to and more clinically comprehensive information than CMR, the currently recommended antibiotic stewardship programme mortality indicator. [ABSTRACT FROM AUTHOR]