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Alkylation of Ethyl 2-Aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylates with Benzyl Halides.
- Source :
-
Russian Journal of Organic Chemistry . Feb2024, Vol. 60 Issue 2, p243-251. 9p. - Publication Year :
- 2024
-
Abstract
- The alkylation of ethyl 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylates with substituted benzyl halides resulted in the selective formation of O-alkoxy derivatives. N-Alkylation products (1-alkylimidazole 3-oxides) were obtained by the condensation reaction from acyclic starting compounds. In the presence of the 2-hydroxyphenyl substituent in the 2-position of the imidazole ring, selective monoalkylation involving the hydroxyl substituent on the imidazole nitrogen takes place. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BENZYL halides
*CONDENSATION reactions
*ALKYLATION
*IMIDAZOLES
*ALKOXY compounds
Subjects
Details
- Language :
- English
- ISSN :
- 10704280
- Volume :
- 60
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Russian Journal of Organic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 176996976
- Full Text :
- https://doi.org/10.1134/S107042802402009X