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Non-Faradaic aptasensor based on NH2-GO/PPy for the detection of 17β-estradiol.
- Source :
-
Journal of the Iranian Chemical Society . May2024, Vol. 21 Issue 5, p1213-1223. 11p. - Publication Year :
- 2024
-
Abstract
- 17ß-Estradiol (E2) is an endocrine-disrupting chemical that has become a matter of concern across the globe for more than a decade due to potential health risks. This study reports facile methods to fabricate label-free aptasensor based on the non-Faradaic impedance mode using amine-functionalized graphene oxide polypyrrole (NH2-GO/PPy)-modified gold interdigitated electrode for direct capacitive detection of 17β-estradiol. The as-prepared NH2-GO/PPy nanocomposites have been successfully characterized by field-emission scanning electron microscopy (FESEM), atomic force microscopy, Fourier transform infrared spectroscopy, and electrochemical impedance spectroscopy. The results show that NH2-GO/PPy/IDE was able to detect E2 binding through aptamer conformational change by simply observing the capacitance change before and after immobilization. In addition, the biosensor showed a dynamic range of detection from 100 nM to 1 pM with a low detection limit of about 0.13 pM. The recoveries result also presented in this paper was validated using HPLC exhibited high sensitivity for bisphenol-A (BPA) detection and was successfully applied to detect E2 in real water samples with good recoveries. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1735207X
- Volume :
- 21
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of the Iranian Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 176996197
- Full Text :
- https://doi.org/10.1007/s13738-024-02987-y