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Self-Reported Cancer-Related Cognitive Impairment in Patients With Breast Cancer Is Associated With Potassium Channel Gene Polymorphisms.
- Source :
-
Oncology Nursing Forum . May2024, Vol. 51 Issue 3, p263-274. 21p. - Publication Year :
- 2024
-
Abstract
- OBJECTIVES: To evaluate for associations of polymorphisms for potassium channel genes in patients with breast cancer who were classified as having high or low-moderate levels of cancer-related cognitive impairment (CRCI). SAMPLE & SETTING: 397 women who were scheduled to undergo surgery for breast cancer on one breast were recruited from breast care centers located in a comprehensive cancer center, two public hospitals, and four community practices. METHODS & VARIABLES: CRCI was assessed using the Attentional Function Index prior to and for six months after surgery. The attentional function classes were identified using growth mixture modeling. RESULTS: Differences between patients in the high versus low-moderate attentional function classes were evaluated. Six single nucleotide polymorphisms for potassium channel genes were associated with low-moderate class membership. IMPLICATIONS FOR NURSING: The results contribute to knowledge of the mechanisms for CRCI. These findings may lead to the identification of high-risk patients and the development of novel therapeutics. [ABSTRACT FROM AUTHOR]
- Subjects :
- *COGNITION disorder risk factors
*DNA analysis
*SELF-evaluation
*RISK assessment
*RESEARCH funding
*BREAST tumors
*POTASSIUM
*QUESTIONNAIRES
*FISHER exact test
*MULTIPLE regression analysis
*CANCER patients
*DESCRIPTIVE statistics
*CHI-squared test
*MANN Whitney U Test
*GENETIC polymorphisms
*GENE expression
*NUCLEOTIDES
*ODDS ratio
*COGNITION disorders
*CONCEPTUAL structures
*DATA analysis software
*CONFIDENCE intervals
*ALLELES
*GENOTYPES
*GENETICS
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 0190535X
- Volume :
- 51
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Oncology Nursing Forum
- Publication Type :
- Academic Journal
- Accession number :
- 176967865
- Full Text :
- https://doi.org/10.1188/24.ONF.263-274