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New Molecular Concepts of Barrett’s Esophagus: Clinical Implications and Biomarkers
- Source :
-
Journal of Surgical Research . May2005, Vol. 125 Issue 2, p189-212. 24p. - Publication Year :
- 2005
-
Abstract
- Barrett’s esophagus (BE) represents the most serious histological consequence of gastroesophageal reflux disease (GERD) that develops in 5–10% of patients with GERD. Given that BE is the only known precursor to esophageal adenocarcinoma (EA), a systematic endoscopic biopsy protocol can detect EAs at an early stage. However, endoscopic and histopathological evaluation of BE are not adequate for effective screening of high risk patients. Therefore, molecular abnormalities associated with BE have been considered as surrogate markers and their use as such is proposed. Flow cytometry is the most useful adjunct to histology, and ploidy status of BE is an independent risk factor. Cyclin D1 overexpression is inversely correlated with survival in EA. C-erbB2 (+) patients have poorer prognosis. High plasma adenomatous polyposis coli levels correlate with reduced patient survival. p53 expression allows patient risk for EA stratification. Nuclear factor-κB overexpression inversely correlates with good response to adjuvant chemotherapy and radiotherapy in EA. Patients with cyclooxygenase-2 overexpression have reduced survival rates. Increased E-cadherin staining is associated with shorter survival in EA patients who received chemoradiotherapy. Finally, existing data cannot rule out a correlation between EA and colorectal tumors. Seventeen BE molecular alterations yielded noteworthy clinical implications. Apart from endoscopy and histology, these data allow for better risk stratification for patients with BE and for more efficient and timely therapeutic approaches. [Copyright &y& Elsevier]
- Subjects :
- *ESOPHAGEAL cancer
*CLINICAL pathology
*DRUG therapy
*GASTROESOPHAGEAL reflux
Subjects
Details
- Language :
- English
- ISSN :
- 00224804
- Volume :
- 125
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Surgical Research
- Publication Type :
- Academic Journal
- Accession number :
- 17696184
- Full Text :
- https://doi.org/10.1016/j.jss.2004.12.022