Fetal cardiac functional changes in pregnancies with Behcet's disease: A case-control study.

Behcet's disease usually progresses with remission during pregnancy, but early subtle changes might be detected in the heart of these fetuses due to inflammation. We aimed to evaluate the cardiac functions in fetuses of pregnant women with Behcet's disease (BD). Prospective case-control study. This prospective study enrolled pregnant women diagnosed with Behcet's disease before pregnancy. Twenty-four pregnancies with Behcet's disease and 48 healthy pregnancies were included at 32–34 gestational weeks. Pulsed-wave Doppler and tissue Doppler imaging (TDI) were used to assess cardiac functions. Right ventricle (RV) E (early) wave and left ventricle (LV) E were significantly increased in pregnancies with BD (p =.008, p =.041, respectively). Decreased right ventricle E' (peak systolic velocity) was detected with TDI in the case group (6.2 ± 0.5, p <.001). E/E' ratios for RV and LV were significantly increased in the case group (p <.001, p =.001, respectively). The correlation between the duration of the disease and fetal cardiac functions was also evaluated. For RV, E (r = 0.735, p <.001), E' (r = −0.735, p <.001), E/E' (r = 0.894, p <.001), were strongly correlated with the disease duration. The study also showed the correlation between disease duration and LV E' (r = −0.735, p =.005), LV E (r = 0.750, p <.001), and LV E/E' (r = 0.820, p <.001). This is the first study to evaluate the fetal cardiac functions in fetuses of pregnancies with BD. Although BD usually progresses with remission during pregnancy, early subclinical diastolic changes might occur in the heart of these fetuses due to inflammation. • Little is known about how inflammatory diseases such as Behcet's Disease affect the fetal heart. • Fetal echocardiography has been widely used to assess changes in cardiac function in fetuses of high-risk pregnancies. • Fetuses of pregnant women with Behcet's disease may have subtle cardiac changes. [ABSTRACT FROM AUTHOR]