健康体检人群非酒精性脂肪肝病的影响因素分析 及对肾功能和亚临床动脉粥样硬化的影响.

Objective: To analyze the influencing factors of nonalcoholic fatty liver disease (NAFLD) in healthy people, and to observe the changes of renal function and subclinical atherosclerosis relate indexes in NAFLD patients. Methods: 1398 patients who underwent general health examination in The Second Medical Center of Chinese PLA General Hospital from May 2019 to August 2022 were selected as study subjects, NAFLD was diagnosed as case group among study subjects, and the rest as control group. The influencing factors of NAFLD in healthy people were analyzed by univariate and multivariate logistic regression analysis, and the changes of renal function [serum creatinine (Scr), urea nitrogen (BUN), serum uric acid (UA), incidence of impaired renal function] and subclinical atherosclerosis-related indicators [intima-media thickness (cIMT), common carotid artery stiffness index (β), vascular pressure-strain elasticity coefficient (Ep), and single-point pulse wave velocity (PWVβ)] in NAFLD patients were observed. Results: Of the 1398 subjects, 1372 completed the survey, with a completion rate of 98.14% (1372/1398). 184 cases were diagnosed as NAFLD among study subjects, which were included in case group, and the remaining 1188 cases were included in control group.The detection rate was 13.41% (184/1372). The results of univariate analysis showed that, the incidence of NAFLD was related to gender, body mass index, education level, nature of work, place of residence, exercise, preference for meat, preference for sweets, history of hypertension, history of hyperlipidemia, history of diabetes, family history of NAFLD, TG, fasting blood glucose, HDL-C, LDL-C and TC (P<0.05). The results of multivariate logistic regression analysis showed that, male gender, high body mass index, preference for meat, preference for sweets, high TG, high fasting blood glucose, high LDL-C, high TC and low HDL-C were risk factors for NAFLD, while exercise≥30 min/d was a protective factor for NAFLD (P<0.05). The Scr, BUN, UA and incidence of renal dysfunction in case group was higher than that in control group (P<0.05). The cIMT, β, Ep and PWVβ in case group were higher than those in control group (P<0.05). Conclusion: Male gender, high body mass index, preference for meat, preference for sweets, high TG, high fasting blood glucose, high LDL-C, high TC and low HDL-C were risk factors for NAFLD, while exercise≥30 min/d was a protective factor for NAFLD. NAFLD patients have the risk of renal function damage and subclinical atherosclerosis, which is worthy of clinical attention. [ABSTRACT FROM AUTHOR]