Does morphine attenuate the Inhibition of Platelet Aggregation for both oral and parenteral P2Y12 inhibitors?

• Cangrelor provides lower and potentially suboptimal IPA compared with tirofiban at light transmittance aggregometry. • This analysis demonstrates that morphine attenuates the antiplatelet effects of cangrelor and oral P2Y 12 inhibitors. • An effect of morphine on P2Y 12 inhibitors other than delayed/impaired absorption should be further investigated. [ABSTRACT FROM AUTHOR]