Fractional Order Mathematical Modelling of HFMD Transmission via Caputo Derivative.

This paper studies a nonlinear fractional mathematical model for hand, foot, and mouth Disease (HFMD), incorporating a vaccinated compartment. Our initial focus involves establishing the non-negativity and boundedness of the fractional order dynamical model. The existence and uniqueness of the system are discussed using the Caputo derivative operator formulation. Applying a fixed-point approach, we obtain results that confirm the presence of at least one solution. We analyze the stability behavior at the two equilibrium points (disease-free and endemic states) of the model and derive the basic reproduction number. Numerical simulations are conducted using the fractional Euler approach, and the simulation results confirm our analytical conclusions. This comprehensive approach enhances the understanding of HFMD dynamics and facilitates the policy making of health care centers to control the further spread of this disease. [ABSTRACT FROM AUTHOR]