Fried Frailty Phenotype Questionnaire scores and postoperative patient‐reported outcomes of patients undergoing major abdominal cancer surgery: A secondary analysis.

Aim: This study aimed to evaluate the effects of Fried Frailty Phenotype Questionnaire (FFPQ) scores on patient‐reported postoperative outcomes. Methods: This secondary analysis of a prospective observational study included 230 inpatients aged ≥65 years undergoing elective abdominal cancer surgery. The primary outcome was the Quality of Recovery‐15 score on postoperative days 2, 4 and 7. The secondary outcomes included disability‐free survival, defined as a 12‐item World Health Organization Disability Assessment Schedule 2.0 score of <16% at 3 months. The associations of the FFPQ scores, ranging from 0 (robust) to 5 (frailty), with the primary and secondary outcomes were assessed using multiple analysis. Results: After confirming the linearity of the FFPQ score for the outcomes, multiple regression analysis adjusted for prominent factors showed that the FFPQ score was a significant factor influencing the decrease in the Quality of Recovery‐15 score on postoperative day 2 (β = −2.67, 95% confidence interval −5.20, −0.15), 4 (β = −3.54, 95% confidence interval −5.77, −1.30) and 7 (β = −3.70, 95% confidence interval −5.75, −1.65). The adjusted odds ratio of the FFPQ score for disability‐free survival postoperatively was 0.66 (95% confidence interval 0.49–0.90). Conclusions: Patients with higher FFPQ scores before elective major abdominal cancer surgery were likely to have lower postoperative Quality of Recovery‐15 scores and poor disability‐free survival. Geriatr Gerontol Int 2024; 24: 464–469. Patients with higher Fried Frailty Phenotype Questionnaire scores had lower postoperative Quality of Recovery‐15 scores and were unlikely to have disability‐free survival at 3 months postoperatively. Frailty assessment using the Fried Frailty Phenotype Questionnaire might assist geriatricians, surgeons and anesthesiologists in predicting postoperative recovery, underscoring the importance of preoperative frailty assessment. [ABSTRACT FROM AUTHOR]