Incidence trends of lentigo maligna and lentigo maligna melanoma in the United States from 2000 to 2019.

Background: Information on lentigo maligna (LM) and lentigo maligna melanoma (LMM) in the 21st century is scarce. We aimed to elucidate the incidence of LM and LMM using the Surveillance, Epidemiology, and End Results (SEER) 17 Registries. Methods: The data of patients diagnosed between 2000 and 2019 were extracted from the SEER database. The percentage of LM/LMM cases among all melanoma patients, age‐standardized incidence rates, estimated annual percentage changes, and the cumulative incidence of LMM after LM were calculated. Results: The SEER data yielded 95,175 patients with LM/LMM between 2000 and 2019. Cases of LM/LMM accounted for 15.7% of all melanomas. The age‐standardized incidence per 100,000 person‐years for LM increased from 4.16 to 5.61 and for LMM from 1.33 to 2.35 between 2000 and 2019. The annual increase in incidence of LM was 2.42%, and that of LMM was 3.32%. The cumulative incidence of LMM after a primary LM after 10‐year follow‐up was 0.94%. Conclusions: This study provides the first comprehensive analysis of the epidemiological status of LM/LMM in the United States in the 21st century using the population‐based SEER data. [ABSTRACT FROM AUTHOR]