Single‐cell RNA sequencing of pediatric renal tissues revealed the potential relationship between immunoglobulin A nephropathy and immunoglobulin A vasculitis with nephritis.

A study published in the journal Clinical & Translational Medicine examined the relationship between immunoglobulin A nephropathy (IgAN) and immunoglobulin A vasculitis with nephritis (IgAVN) using single-cell RNA sequencing (scRNA-seq) of pediatric renal tissues. The study found similarities and distinctions between the two kidney diseases, providing insights into their pathogenesis, diagnosis, and treatments. The analysis revealed differences in cell type proportions, energy metabolism, and fibrosis levels between IgAN and IgAVN. These findings have the potential to impact future diagnostic approaches, treatment options, and predictive outcomes for patients with these conditions. The study was conducted by a team of researchers from the Children's Hospital, Zhejiang University School of Medicine. [Extracted from the article]