Human tumour vessel heterogeneity in ovarian cancer and its association with response to neoadjuvant chemotherapy.

This article explores the relationship between tumor vessel heterogeneity and the response to neoadjuvant chemotherapy in ovarian cancer patients. The study utilized human intravital microscopy to directly observe tumor vessel characteristics. The findings revealed that tumor vessels in patients had smaller diameters, lower velocities, and a higher proportion of non-functional vessels compared to normal tissues. Patients who had a poorer response to chemotherapy had a lower number and density of functional blood vessels and a higher number of non-functional vessels. The study suggests that tumor vessel heterogeneity may play a role in determining treatment outcomes in ovarian cancer. Additionally, the article discusses the correlation between pathologic tumor vessel measurements and human intravital microscopy measurements. The study found a significant correlation between pathologic vessel density and HIVM vessel density, as well as between pathologic vessel diameter and HIVM-measured diameters. The researchers also observed that patients who had a complete or partial response to neoadjuvant chemotherapy had higher vessel density and larger blood vessels compared to those with stable or progressive disease. The study suggests that human intravital microscopy can be utilized to monitor drug delivery and investigate tumor vessel heterogeneity. [Extracted from the article]