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Poly(I:C)/c-GAMP/Alum ternary adjuvant system synergistically enhances the immunogenicity of glycopeptide antigen.
- Source :
-
Journal of Carbohydrate Chemistry . 2023, Vol. 42 Issue 7-9, p252-267. 16p. - Publication Year :
- 2023
-
Abstract
- The highly glycosylated mucin 1 (MUC1) serves as a promising target for cancer vaccines. However, the weak immunogenicity of MUC1 greatly impedes its application. Here, we covalently linked a MUC1 glycopeptide to carrier protein bovine serum albumin (BSA), and the resulting BSA-MUC1 conjugate was integrated with a ternary adjuvant system comprising TLR3 agonist poly(I:C), STING agonist c-GAMP, and Alum adjuvant. Compared to adjuvant-free and Alum-adjuvanted groups, the ternary adjuvant group induced 18.3- and 10.9-fold increases in MUC1-specific IgG titers, and effectively suppressed tumor growth. These findings may propose a straightforward yet highly effective strategy for designing vaccines, offering promising prospects in cancer treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TERNARY system
*IMMUNE response
*CARRIER proteins
*CANCER vaccines
*SERUM albumin
Subjects
Details
- Language :
- English
- ISSN :
- 07328303
- Volume :
- 42
- Issue :
- 7-9
- Database :
- Academic Search Index
- Journal :
- Journal of Carbohydrate Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 176763458
- Full Text :
- https://doi.org/10.1080/07328303.2024.2332342