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Visible-light-driven three-component annulation for the synthesis of highly functionalized 2-iminothiazolidin-4-ones without photocatalysts.
- Source :
-
Green Chemistry . 4/21/2024, Vol. 26 Issue 8, p4477-4483. 7p. - Publication Year :
- 2024
-
Abstract
- We have developed a photocatalyst/base/metal-free, visible-light-driven three-component annulation protocol to access fully substituted 2-iminothiazolidin-4-one derivatives from isothiocyanates, amines, and aryl diazoacetates using a low-energy white light source at room temperature in open air. The [2 + 2 + 1] reaction undergoes successive C–N/C–S bond formation in one pot. This transformation proceeds under extremely mild conditions with a good yield and a good functional group tolerance. Mechanistic studies showed that the reaction involves the formation of free carbene intermediates from aryl diazoacetates under visible light irradiation. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14639262
- Volume :
- 26
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Green Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 176761550
- Full Text :
- https://doi.org/10.1039/d4gc00375f