Modulation of AQP2 localization and water reabsorption.

The article discusses the regulation of water reabsorption in the collecting ducts of the kidney, focusing on the role of aquaporin 2 (AQP2) and the lipopolysaccharide-responsive beige-like anchor protein (LRBA). LRBA acts as an anchoring protein for vasopressin/PKA-mediated phosphorylation of AQP2, influencing its localization from recycling endosomes to the apical membrane. The study sheds light on a new layer of regulation in water reabsorption and provides a basis for further research on LRBA's role in protein trafficking and water balance in the kidney. [Extracted from the article]