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Genome-wide association studies have problems due to confounding: Are family-based designs the answer?
- Source :
-
PLoS Biology . 4/12/2024, Vol. 22 Issue 4, p1-4. 4p. - Publication Year :
- 2024
-
Abstract
- Genome-wide association studies (GWASs) can be affected by confounding. Family-based GWAS uses random, within-family genetic variation to avoid this. A study in PLOS Biology details how different sources of confounding affect GWAS and whether family-based designs offer a solution. Genome-wide association studies (GWASs) can be affected by confounding, but family-based GWASs use random, within-family genetic variation to avoid this. This Primer explores a study in PLOS Biology which asks how different sources of confounding affect GWASs and whether family-based designs offer a solution. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENOME-wide association studies
*GENETIC variation
*CONFOUNDING variables
Subjects
Details
- Language :
- English
- ISSN :
- 15449173
- Volume :
- 22
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- PLoS Biology
- Publication Type :
- Academic Journal
- Accession number :
- 176592323
- Full Text :
- https://doi.org/10.1371/journal.pbio.3002568