CAN WE USED A COMPLETE BLOOD COUNT FOR EARLY DIAGNOSTIC IN COLORECTAL CANCER?

Background. Between colorectal cancer (CRC) and systemic inflammation seems to be a powerful relationship. Inflammatory status can be quantified with analytical markers like neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), mean platelet volume (MPV) and platelet/hemoglobin ratio (PHR). The combined diagnostic efficacy of these four biomarkers in CRC remains unknown and need more complex researches. Aims: In this study we want to investigate the efficiency of NLR, PLR, MVP and PHR as a diagnostic tool in newly diagnosed patients with CRC. Methods. We performed a retrospective case control study in which we included patients who were diagnosticated with colorectal cancer on histopathological examination and a control group with patients without colorectal cancer on biopsy but who had different types of polyps. Patients with acute infection, acute gastrointestinal disease, cirrhosis, other inflammatory diseases and incomplete data were excluded from the study. The final study group included 38 patients with colorectal cancer and the control group was formed by 61 patients with polyps (tubular adenoma, tubule villous adenoma or sessile serrated) at colonoscopy. Results. The mean value of the neutrophil/lymphocyte ratio is statistically higher in patients with colorectal cancer compared with those without colorectal cancer (p <0.006), also the mean value of the hemoglobin was significantly lower in patients with colorectal cancer (p<0.001), but the mean value of the mean platelet volume was not statistically different between the groups (p=0.278). The mean value of platelet/lymphocyte ratio was significantly higher in patients with colorectal cancer (p = 0.012). Platelet to hemoglobin ratio, was statistically higher in patients with colorectal adenocarcinoma in comparison with patients with benign lesions (p = 0.001). Conclusions. In conclusion, parameters derived from complete blood count could be used to identify patients with high risk of colorectal cancer before colonoscopy is performed. [ABSTRACT FROM AUTHOR]