Evaluation of Antibacterial, Antioxidant and Immunomodulatory Potential of Mitragyna parvifolia Leaves-Assisted Fe2O3 Nanoparticles.

This work includes the use of leaves of Mitragyna parvifolia for green synthesis of Fe 2 O 3 nanoparticles ( Fe 2 O 3 NPs), which offers a sustainable eco-friendly approach. Characterization of synthesized Fe 2 O 3 NPs was done by UV-visible, FTIR spectroscopy, XRD and FESEM studies. FTIR exhibited the existence of Fe-O, O–H and COO–Fe stretching owing to the occurrence of the carboxylic group. FESEM analysis revealed that the average size of Fe 2 O 3 NPs was 92 nm, which varies in their shape. The study also includes the determination of antibacterial, in vitro antioxidant and immunomodulatory efficacy of synthesized Fe 2 O 3 NPs. Results suggested that Fe 2 O 3 NPs exhibit potent antibacterial efficacy against B. subtilis and S. aureus, gram-positive as well as E. coli and P. aureginosa, gram-negative bacterial strains used in this study. The study exhibited significant (p < 0.01) in vitro antioxidant and immunomodulatory potential of synthesized Fe 2 O 3 NPs against concanavalin-A activated Wistar albino rat's splenocytes. The green synthesized Fe 2 O 3 NPs using M. parvifolia leaves may offer a novel approach in the medicinal and immunological field to overcome oxidative stress as well as enhance immune responses for potential health benefits of human beings. [ABSTRACT FROM AUTHOR]