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Promotion of 14-3-3ζ/Heme Oxygenase-1 Axis on Endotoxin-Induced Uveitis and Microglia Ferroptosis in Mice.

Authors :
Li, Mohan
Gao, Sijia
Wen, Yu
Yong, Liang
Tao, Liming
Source :
Ocular Immunology & Inflammation. Apr2024, p1-7. 7p. 5 Illustrations.
Publication Year :
2024

Abstract

PurposeMethodsResultsConclusionUveitis is a common, sight-threatening inflammatory ocular disease and is the main cause of blindness, which is caused by autoimmune response, infection, and injury. The contribution of 14-3-3ζ in uveitis remains obscure. This study aims to investigate the role of 14-3-3ζ in regulating ferroptosis in retinal inflammation and its contribution to uveitis.A lipopolysaccharide (LPS)-induced uveitis mouse model and BV-2 cell line were used to examine the effect of LPS stimulation on the expression of 14-3-3ζ and ferroptosis in microglia. The expression of heme oxygenase-1 (HO-1) was also analyzed to understand its role in promoting microglial ferroptosis.We found that LPS stimulation increased the expression of 14-3-3ζ and promoted ferroptosis in microglia. Additionally, 14-3-3ζ was found to promote microglial ferroptosis by stabilizing the expression of HO-1. These findings suggest that the 14-3-3ζ/HO-1 axis plays a crucial role in promoting microglial ferroptosis in retinal inflammation.The study provides valuable insights into the mechanisms underlying uveitis and highlights the potential of the 14-3-3ζ/HO-1 axis as a therapeutic target for the disease. Further research in this area could lead to the development of preventive and therapeutic strategies for uveitis. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09273948
Database :
Academic Search Index
Journal :
Ocular Immunology & Inflammation
Publication Type :
Academic Journal
Accession number :
176528500
Full Text :
https://doi.org/10.1080/09273948.2024.2328784