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Two new bibenzyl methylglucosides as SIRT3 activators obtained through microbial transformation.
- Source :
-
Journal of Asian Natural Products Research . Feb2024, Vol. 26 Issue 2, p269-279. 11p. - Publication Year :
- 2024
-
Abstract
- Microbial transformation of dihydroresveratrol (DHRSV) using Beauveria bassiana has produced two new methylglucosylated derivatives of DHRSV (1 and 2), whose structures were characterized as 4′-O-(4″-O-methyl-β-D-glucopyranosyl)-dihydroresveratrol (4′-O-MG DHRSV, 1) and 3-O-(4″-O-methyl-β-D-glucopyranosyl)-dihydroresveratrol (3-O-MG DHRSV, 2) on the basis of spectroscopic methods. They showed moderate SIRT3 agonistic activity, and compound 2 exhibited the best deacetylation of 406.63% at 10 μM. The activity of 2 increased by 3.12-fold compared with that of DHRSV, since 2 performed better in molecular docking assay (GScore −8.445). [ABSTRACT FROM AUTHOR]
- Subjects :
- *COMPUTER-assisted molecular modeling
*IN vitro studies
*NUCLEAR magnetic resonance spectroscopy
*LIQUID chromatography-mass spectrometry
*RESEARCH funding
*ELECTRON microscopy
*FUNGI
*BIOLOGICAL products
*CULTURE media (Biology)
*BIOTRANSFORMATION (Metabolism)
*REACTIVE oxygen species
*INFRARED spectroscopy
*GLYCOSIDES
*MOLECULAR structure
*SPECTRUM analysis
*ELECTROSPRAY ionization mass spectrometry
*TRANSFERASES
*DATA analysis software
*FLUORIMETRY
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 26
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 176495368
- Full Text :
- https://doi.org/10.1080/10286020.2023.2283483