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Association of single nucleotide polymorphism at BMP2 gene with iron deficiency status among anaemic patients in Hospital Universiti Sains Malaysia.
- Source :
-
Egyptian Journal of Medical Human Genetics . 4/3/2024, Vol. 25 Issue 1, p1-8. 8p. - Publication Year :
- 2024
-
Abstract
- Background: Iron deficiency contributes for over half of all anaemia cases, especially among women and children. Iron deficiency anaemia remains a serious public health concern worldwide. The aim of this study is to determine the association between the single nucleotide polymorphism rs235756 in the bone morphogenetic protein 2 (BMP2) gene and iron deficiency status. Results: 104 total anaemic samples were selected from Hospital Universiti Sains Malaysia. ARMS-PCR was performed to genotype the rs235756 SNP in the 104 samples. The genotype distribution of BMP2 rs235756 showed that AG genotypes had the highest frequency 51(86.4%) followed by GG 6(10.2%) and AA 2(3.4%) in IDA group, whereas AG 42(93.3%), AA 2(4.4%) and GG 1(2.2%) were found in the other anaemia group. The minor allele frequency in BMP 2 rs235756 from this study (0.514) was not similar to the East Asian (EAS) population (0.135); however, the allelic frequency showed significant association between these two. The mean of total iron binding capacity level differed significantly between homozygous-dominant AA and AG + GG genotypes (P < 0.05) but no significant difference for the mean of haematological parameter, ferritin and serum iron. Conclusions: In future clinical settings, this finding can potentially be as a guide in the early prediction for IDA patients through the genetic testing. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 11108630
- Volume :
- 25
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Egyptian Journal of Medical Human Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 176452050
- Full Text :
- https://doi.org/10.1186/s43042-024-00511-8