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Effect of Ambrosia arborescens Mill. ethanolic extract on breast cancer induced in rats.
- Source :
-
Veterinary World . Mar2024, Vol. 17 Issue 3, p700-704. 5p. - Publication Year :
- 2024
-
Abstract
- Background and Aims: Ambrosia arborescens Mill. (A. arborescens) is an aromatic plant used in traditional medicine as an anti-inflammatory, anti-tussive, anti-rheumatic, and anti-diarrheal agent. This study aimed to evaluate the effect of A. arborescens Mill. on a Rattus norvegicus var. albinus-induced breast cancer model. Materials and Methods: We collected A. arborescens from the province of Julcán, La Libertad Region, Per, and prepared an ethanolic extract using pulverized leaves macerated in 96° ethanol for 72 h with magnetic stirring. In the evaluation of anticancer activity, four experimental groups with 10 female rats each were formed: Group I (Control-7,12-dimethylbenz[a] anthracene [DMBA]), which received DMBA (single dose) and physiological saline solution for 4 months, and Groups II, III, and IV, which received DMBA (single dose) and 200, 400, and 600 mg/kg/day of the ethanolic extract of A. arborescens, respectively, for 4 months. Results: The DMBA control group presented histological characteristics of ductal carcinoma in situ with necrotic and inflammatory areas, whereas the A. arborescens extract group showed a decrease in tumor volume and recovery of the ductal duct. Conclusion: Ethanol extract of A. arborescens leaves decreases tumor development in rats with induced breast cancer, and this effect is dose-dependent. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09728988
- Volume :
- 17
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Veterinary World
- Publication Type :
- Academic Journal
- Accession number :
- 176414236
- Full Text :
- https://doi.org/10.14202/vetworld.2024.700-704