A redeemed strategy for molecular autopsy in unexplained infant deaths.

This document discusses the challenges of diagnosing the causes of unexplained child deaths and presents a study on the use of molecular autopsy to identify genetic variations associated with these deaths. Traditional autopsies are not always acceptable to parents due to religious and cultural beliefs, so molecular autopsy, which involves DNA sequencing, offers a promising alternative. The study used stored neonatal dried blood spots to conduct clinical exome sequencing and found that 88.9% of cases had genetic variations associated with the cause of death. The study suggests that molecular autopsies using clinical exome sequencing can be a feasible and effective method for investigating unexplained child deaths. [Extracted from the article]