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Akut Myeloid Lösemi Hastaları İçin Kinolon Profilaksisinde Levofloksasin ve Moksifloksasin Kullanımının Prospektif Değerlendirmesi.
- Source :
-
Klimik Journal / Klimik Dergisi . Mar2024, Vol. 37 Issue 1, p54-58. 5p. - Publication Year :
- 2024
-
Abstract
- Objective: The study aimed to evaluate the clinical effects of levofloxacin (LEVO) and moxifloxacin (MOXI) prophylaxis during the treatment of acute myeloid leukemia (AML). Methods: This study had a prospective observational design and included AML patients who were scheduled for standard remission-induction (RI) or consolidation (C) chemotherapy. Prophylactic LEVO or MOXI was started at a ratio of 1:1 when neutropenia developed, and two groups were created. The primary endpoint was the frequency of febrile neutropenia (FN) and the time to FN. Results: 120 patients (60 patients in each group) were enrolled in the study. The frequency of FN tended to be higher in the LEVO group but was statistically insignificant (82.1% vs. 75.5%; p=0.702). The time to FN was 10.8±5.7 days and 10.1±5.7 days in the LEVO and MOXI groups, respectively (p=0.393). Microorganisms were izolated in 50.8% of patients who developed FN. The documented infection and bacteremia rate tended to be higher in the MOXI group (71.1% vs. 56.6%; p=0.331 and 87.5% vs. 80.5%; p=0.906). The rates of quinolone resistance were 69.2% and 75% in the LEVO and MOXI groups, respectively (p=0.451). The frequency of FN was higher during the RI phase than the C phase (89.1% vs. 70%; p=0.010). The frequency of documented infection was higher during the C phase than during the RI phase (77.1% vs. 49.1%; p=0.008). Conclusion: This study showed that prophylactic MOXI and LEVO have similar efficacy in AML patients. [ABSTRACT FROM AUTHOR]
Details
- Language :
- Turkish
- ISSN :
- 1301143X
- Volume :
- 37
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Klimik Journal / Klimik Dergisi
- Publication Type :
- Academic Journal
- Accession number :
- 176385469
- Full Text :
- https://doi.org/10.36519/kd.2024.4696