The Effect of Dalargin on the Level of Corticosterone in Rats with Different Individual Typological Features of Behavior in the PTSD Model.

The effect of the synthetic analogue of leu-enkephalin (dalargin) on the level of corticosterone in the blood and the mass of the adrenal glands in rats with various typological features of behavior in the model of post-traumatic stress disorder (PTSD) was studied. Groups were formed: active low-anxiety (ALA) and high-anxiety (AHA), as well as passive low-anxiety (PLA) and high-anxiety (PHA) rats. Each of the four groups of rats was divided into three subgroups, where subgroup 1 is an intact control. Twenty days after the first stressful exposure, rats from subgroup 3 were injected intramuscularly with dalargin for seven days, and rats from subgroup 2 were injected with saline solution. It was found that the course of injections of dalargin into rats in the PTSD model had a positive effect on the studied indicators only in the group of active high-anxiety animals. [ABSTRACT FROM AUTHOR]