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Evaluation of the Antifungal and Antiproliferative Properties of the Lichen Roccella tinctoria DC. Extracts and Main Components.

Evaluation of the Antifungal and Antiproliferative Properties of the Lichen Roccella tinctoria DC. Extracts and Main Components.

Authors :
Frezza, Claudio
Fraioli, Dalia Rosa
Conti, Francesca
Nicolosi, Roberta Maria
Scipione, Luigi
Serafini, Ilaria
Petrucci, Rita
Di Matteo, Paola
Rocco, Daniele
Di Giacomo, Silvia
Di Sotto, Antonella
Bonincontro, Graziana
Simonetti, Giovanna
Garzoli, Stefania
De Vita, Daniela
Foddai, Sebastiano
Source :
Pharmaceutics. Mar2024, Vol. 16 Issue 3, p331. 22p.
Publication Year :
2024

Abstract

In this work, phytochemical analysis on different extracts of Roccella tinctoria DC. was reported using different techniques with respect to the past. Twenty volatile and three non-volatile compounds were identified, some of which were found in this species for the first time. The methanolic extracts and their non-volatile components were then evaluated for their antitumor effects in cancerous A549 and Mz-ChA-1 cells and for their tolerability in non-cancerous BEAS-2B and H69 cells, showing IC50 values from 94.6 µg/mL to 416.4 µg/mL, in general. The same extracts and compounds were also tested for their antifungal effects in Candida albicans, with only compound 2 being active, with an MIC50 value of 87 µg/mL. In addition, they were tested for their anti-Candida adhesion activity, anti-Candida biofilm formation, and anti-Candida mature biofilm inhibition, with efficacy percentages generally above 50% but not for all of them. Lastly, the DF3 extract and compounds 1–2 were tested in vivo according to the Galleria mellonella survival assay, showing positive mortality rates above 50% at different concentrations. All these biological assays were conducted on this species for the first time. Comparisons with other lichens and compounds were also presented and discussed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19994923
Volume :
16
Issue :
3
Database :
Academic Search Index
Journal :
Pharmaceutics
Publication Type :
Academic Journal
Accession number :
176367856
Full Text :
https://doi.org/10.3390/pharmaceutics16030331