Back to Search Start Over

Elucidating the pathogenesis behind arteriovenous malformations of the central nervous system: a bibliometric analysis.

Authors :
Astudillo Potes, Maria D.
Bauman, Megan M.J.
Shoushtari, Ali
Winter, Bailey M.
Singh, Rohin
Rahmani, Redi
Catapano, Joshua
Lawton, Michael T.
Source :
Neurosurgical Review. 4/1/2024, Vol. 47 Issue 1, p1-10. 10p.
Publication Year :
2024

Abstract

Arteriovenous malformations (AVMs) are vascular malformations of the central nervous system (CNS) with potential for significant consequences. The exact pathophysiologic mechanism of AVM formation is not fully understood. This study aims to evaluate bibliometric parameters and citations of the literature of AVMs to provide an overview of how the field has evolved. We performed an electronic search on Web of Science to identify the top 100 published and indexed articles with the highest number of citations discussing the pathogenesis of AVMs. This study yielded 1863 articles, of which the top 100 were selected based on the highest total citation count. These articles included 24% basic science, 46% clinical, and 30% review articles. The most-cited article was a clinical article from 2003, and the most recent was published in 2022. The median number of authors was 6, with the highest being 46 for a clinical article. The top 5 journals were identified, with the highest impact factor being 20.1. 13 countries were identified, with the US contributing the most articles (approximately 70%). Regarding genes of investigation, VEGF was one of the early genes investigated, while more interested in RAS/MAPK has been garnered since 2015. There is a growing interest in AVM genomics and pathogenesis research. While progress has been made in understanding clinical aspects and risk factors, the exact pathophysiological mechanisms and genetic basis of AVM formation remain incompletely understood. Further investigation of key genes in AVM pathogenesis can allow identification of potential therapeutic targets. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03445607
Volume :
47
Issue :
1
Database :
Academic Search Index
Journal :
Neurosurgical Review
Publication Type :
Academic Journal
Accession number :
176354442
Full Text :
https://doi.org/10.1007/s10143-024-02367-3