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Association Between Pretreatment Blood 25-Hydroxyvitamin D Level and Survival Outcomes in Patients With Clinically Localized Prostate Cancer: An Updated Meta-Analysis.
- Source :
-
Nutrition & Cancer . 2024, Vol. 76 Issue 5, p395-403. 9p. - Publication Year :
- 2024
-
Abstract
- Studies on the prognostic value of the blood 25-hydroxyvitamin D level have yielded controversial results in prostate cancer (PCa) patients. This updated meta-analysis aimed to evaluate the association between pretreatment 25-hydroxyvitamin D level with survival outcomes among patients with clinically localized PCa. PubMed, Web of Science, and Embase databases were searched to identify studies evaluating the association of pretreatment 25-hydroxyvitamin D level with PCSM and all-cause mortality among clinically localized PCa patients. Ten cohort studies with 10,394 patients were identified. The meta-analysis revealed that PCa patients with the lowest 25-hydroxyvitamin D levels had an increased risk of PCSM (adjusted hazard ratio [HR] 1.52; 95% confidence interval [CI] 1.26-1.83; p < 0.001) and all-cause mortality (adjusted HR 1.31; 95% CI 1.00-1.90; p = 0.047) compared to those with higher reference 25-hydroxyvitamin D level. Subgroup analyses based on different sample sizes, follow-up duration, and adjusted times of blood draw also exhibited a significant association of vitamin D deficiency with the risk of PCSM. Lower pretreatment level of 25-hydroxyvitamin D may be an independent predictor of reduced survival in patients with clinically localized PCa. Measuring the pretreatment blood 25-hydroxyvitamin D level can provide valuable information for risk stratification of survival outcomes in these patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RISK assessment
*VITAMIN D deficiency
*MEDICAL information storage & retrieval systems
*RESEARCH funding
*PROSTATE tumors
*EVALUATION of medical care
*META-analysis
*METASTASIS
*LONGITUDINAL method
*SYSTEMATIC reviews
*MEDLINE
*SEARCH engines
*CANCER patient psychology
*CONFIDENCE intervals
*COMPARATIVE studies
*ONLINE information services
*VITAMIN D
*DISEASE risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 01635581
- Volume :
- 76
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Nutrition & Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 176341137
- Full Text :
- https://doi.org/10.1080/01635581.2024.2328378