Back to Search
Start Over
Synthesis of Vinyl and 1,3‐Dienyl Sulfones Enabled by Photochemical Excitation of Halogen‐Bonding Complexes.
- Source :
-
Advanced Synthesis & Catalysis . 3/19/2024, Vol. 366 Issue 6, p1422-1429. 8p. - Publication Year :
- 2024
-
Abstract
- The photochemical catalyst‐free radical‐based synthesis of vinyl and 1,3‐dienyl sulfones is disclosed. Mechanistic investigations support that the transformations rely on a visible‐light‐promoted activation of a halogen‐bonding complex, which is formed between an alkenyl (or 1,3‐dienyl) bromide and a sodium sulfinate salt. The reactions exhibit a wide functional group tolerance (compatible with heteroatoms, electron‐withdrawing and electron‐donating groups), finding application in the structural modification of biologically relevant molecules. Eventually, a continuous flow protocol was developed to upscale these transformations. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SULFONES
*SODIUM bromide
*FUNCTIONAL groups
*SODIUM salts
*VISIBLE spectra
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 366
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 176295549
- Full Text :
- https://doi.org/10.1002/adsc.202301381