A Comparative Study of Cardioprotective Effect of Three Anesthetic Agents by Measuring Serum Level of Troponin-T after Coronary Artery Bypass Grafting.

Background: Coronary artery bypass grafting (CABG) surgery is a common procedure for revascularization in patients with coronary artery disease. Anesthetic agents used during CABG can impact perioperative myocardial injury. Troponin-T (TnT) is a sensitive biomarker for myocardial injury. This study aims to compare the cardioprotective effects of three anesthetic agents by measuring serum levels of TnT after CABG surgery. Materials and Methods: A prospective comparative study was conducted on 150 patients undergoing elective CABG surgery. Patients were divided into three groups based on the anesthetic agent used: Group A (propofol), Group B (sevoflurane), and Group C (isoflurane). Serum TnT levels were measured at baseline (preoperatively) and at 6, 12, and 24 hours postoperatively. Demographic data, surgical details, and perioperative variables were recorded. Statistical analysis was performed using ANOVA and post-hoc Tukey's test. Results: The mean baseline serum TnT levels were comparable among the three groups (p > 0.05). At 6, 12, and 24 hours postoperatively, Group A showed significantly lower serum TnT levels compared to Group B and Group C (p < 0.05). The mean TnT levels at 24 hours postoperatively were 0.12 ng/mL in Group A, 0.18 ng/mL in Group B, and 0.20 ng/mL in Group C. Conclusion: Propofol-based anesthesia demonstrated superior cardioprotective effects compared to sevoflurane and isoflurane in patients undergoing CABG surgery, as evidenced by lower serum TnT levels postoperatively. Further studies are warranted to elucidate the underlying mechanisms of this cardioprotection and its clinical implications. [ABSTRACT FROM AUTHOR]