A Prospective Clinical Study on Efficacy of Autologousplatelet Rich Fibrin in Chronic Non-Healing Ulcers.

Introduction: Ulcers that do not heal spontaneously through the standard, orderly, timely sequence of repair or on conventional treatment and those persist for more than 6-12 weeks are called as chronic non-healing ulcers. This is a significant health problem and is estimated to affect approximately 2-6 million people in the United States, while its prevalence in the world ranges from 1.9 to 13.1%. The incidence increases with age. 75% of chronic non-healing ulcers are venous ulcers, and the rest is by other causes in comprehensive data. In tropical countries like India, there is a lack of data. A study from one center in India suggests leprosy (40%), diabetes (23%), venous disease (11%), and trauma (13%) as the cause of non healing ulcers. Materials And Methods: This is a Prospective study conducted in the Dermatology Venereology and Leprosy at Tertiary Care teaching Hospital over a period 1 year. All the patients attending to the OPD of Dermatology Venereology and Leprosy who were suffering from chronic non-healing ulcers and satisfying the inclusion and exclusion criteria became the part of the study after taking written consent.patient is explained about the procedure in detail in the local language, and consent is obtained. Results: In this study, out of 30 patients included, the majority of patients are between 46 and 50 years (43.3%), and the mean age of the patients observed was 55.1 years. In this study, out of 30 patients majority were females 16 (53.3%) when compared to males 14 (46.7%). In the present study, the mean area measurement of the ulcer after each sitting of PRF at the end of every week is calculated and it showed a reduction in the mean from 6.068 to 1.729 by the end of 5th week and attained a p-value of <0.001 which is highly significant. In this study, out of 30 patients, the mean percentage improvement in the area of the ulcer at the end of the 5th week is 91.81%. Conclusion: This study authenticates the use of Autologous platelet rich fibrin therapy in the treatment of chronic non-healing ulcers by showing significant improvement in both the size of the wound and the quality of life, vowing to its safety and a being less expensive procedure associated with no or minimal side effects. [ABSTRACT FROM AUTHOR]