肝硬化腹水管理新策略--长期白蛋白治疗.

Ascites is the most frequent decompensating event of cirrhosis. At present, ascites recurs at a high rate due to lack of effective management strategy and is frequently complicated with spontaneous bacterial peritonitis, hepatorenal syndrome, and liver failure, which increase the fatality rate. Albumin treatment for hepatocirrhosic ascites has a long history, but it is limited as an acute or short-term treatment. In contrast, long-term albumin administration represents a completely different treatment paradigm. Results from several recent clinical studies indicate that long-term albumin treatment can be able to modify the disease courses of some decompensated cirrhosis when albumin is given at a sufficient dose for a sufficient time. In this review, we analyze the available data acquired from long-term albumin treatments, trying to establish a secure and effective management scheme involving maximal target population, albumin dose, administration time, and standards for albumin withdrawal, and thus provide references for the clinical practice. [ABSTRACT FROM AUTHOR]