1,4‐Aminoarylation of Butadienes via Photoinduced Palladium Catalysis.

A visible‐light‐induced, three‐component palladium‐catalyzed 1,4‐aminoarylation of butadienes with readily available aryl halides and aliphatic amines has been developed, affording allylamines with excellent E‐selectivity. The reaction exhibits exceptional control over chemo‐, regio‐, and stereoselectivity, a broad substrate scope, and high functional group compatibility, as demonstrated by the late‐stage functionalization of bioactive molecules. Mechanistic investigations are consistent with a photoinduced radical Pd(0)‐Pd(I)‐Pd(II)‐Pd(0) Heck‐Tsuji–Trost allylation cascade. [ABSTRACT FROM AUTHOR]