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Effects of combined sintilimab and chemotherapy on progression-free survival and overall survival in osteosarcoma patients with metastasis.

Authors :
Fan Li
De-bao Zhang
Yue Ma
Yang Song
Xian-liang Duan
Source :
Pakistan Journal of Medical Sciences. Mar/Apr2024, Vol. 40 Issue 4, p648-651. 4p.
Publication Year :
2024

Abstract

Objective: To explore the safety and efficacy of metastatic osteosarcoma treatment with combined sintilimab injection and chemotherapy. Methods: We performed a retrospective analysis of 32 patients with metastatic osteosarcoma admitted to the Affiliated Hospital of Beihua University between January 2019 and June 2020. The sample was divided into an observation group, treated with sintilimab injection combined with chemotherapy (n= 16) and a control group, treated with chemotherapy (n = 16). Clinical efficacy and adverse reactions were compared between the two groups. Results: The overall response rates were 68.75% in the observation group and 31.25% in the control group (p < 0.05). The incidences of adverse reactions were 56.25% in the observation group and 81.25% in the control group. This was not a significant difference. In the observation group, the progression-free survival time was 8.13 ± 2.50 months, and the overall survival time was 22.75 ± 4.95 months. These were both significantly longer than the respective 6.44 ± 1.93 months and 19.69 ± 2.68 months in the control group (p < 0.05). Conclusion: The treatment of metastatic osteosarcoma with combined sintilimab injection and chemotherapy was found to prolong progression-free survival and overall survival time without increasing the incidence of adverse reactions. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1682024X
Volume :
40
Issue :
4
Database :
Academic Search Index
Journal :
Pakistan Journal of Medical Sciences
Publication Type :
Academic Journal
Accession number :
176209525
Full Text :
https://doi.org/10.12669/pjms.40.4.8536