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Gd-EOB-DTPA enhanced MRI based radiomics combined with clinical variables in stratifying hepatic functional reserve in HBV infected patients.
- Source :
-
Abdominal Radiology . Apr2024, Vol. 49 Issue 4, p1051-1062. 12p. - Publication Year :
- 2024
-
Abstract
- Purposes: To evaluate radiomics from Gd-EOB-DTPA enhanced MR combined with clinical variables for stratifying hepatic functional reserve in hepatitis B virus (HBV) patients. Methods: Our study included 279 chronic HBV patients divided 8:2 for training and test cohorts. Radiomics features were extracted from the hepatobiliary phase (HBP) MR images. Radiomics features were selected to construct a Rad-score which was combined with clinical parameters in two models differentiating hepatitis vs. Child–Pugh A and Child–Pugh A vs. B/C. Performances of these stratifying models were compared using area under curve (AUC). Results: Rad-score alone discriminated hepatitis vs. Child–Pugh A with AUC = 0.890, 0.914 and Child–Pugh A vs. B/C with AUC = 0.862, 0.865 for the training and test cohorts, respectively. Model 1 [Rad-score + clinical parameters for hepatitis vs. Child–Pugh A] showed AUC = 0.978 for the test cohort, which was higher than ALBI [albumin-bilirubin] and MELD [model for end-stage liver disease], with AUCs of 0.716, 0.799, respectively (p < 0.001, < 0.001). Model 2 [Rad-score + clinical parameters for Child–Pugh A vs. B/C] showed AUC of 0.890 in the test cohort, which was similar to ALBI (AUC = 0.908, p = 0.760), and higher than MELD (AUC = 0.709, p = 0.018). Conclusion: Rad-score combined with clinical variables stratifies hepatic functional reserve in HBV patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- *RADIOMICS
*HEPATITIS B virus
*FEATURE extraction
*MAGNETIC resonance imaging
Subjects
Details
- Language :
- English
- ISSN :
- 2366004X
- Volume :
- 49
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Abdominal Radiology
- Publication Type :
- Academic Journal
- Accession number :
- 176181603
- Full Text :
- https://doi.org/10.1007/s00261-023-04176-6