اثر بازتوانی با تمرینات ترکیبی منتخب بر بیان ترومبوسپوندین1- و اینترلوکین1- بتا در سلولهای تکهستهای خون در بیماران مردپس از جراحی بایپس عروق کرونر.

Background and Objectives Coronary artery bypass graft (CABG) is a common therapeutic intervention for patients suffering from coronary heart diseases. The aim of this study was to determine the effect of selected combined rehabilitation exercises on the expression of thrombospondin-1 (TSP-1) and interleukin-1 beta (IL-1β) genes in patients following CABG surgery. Subjects and Methods In this semi-experimental study, 20 male patients from Afshar Hospital (Yazd city) after coronary artery surgery were purposefully selected and randomly divided into combined exercise and control groups. he combined exercise group engaged in a 10-week program (30 sessions, three per week) comprising aerobic exercises (15-20 minutes with an intensity of 50-60% of the maximum heart rate) and resistance exercises (10-20 minutes, encompassing three upper limb movements and two lower limb movements; each movement included three sets with 10 repetitions at 30-60% of the maximum repetition). Gene expression was measured using the RealTime PCR method. The data were analyzed using the Paired t-test and One-Way ANOVA at a significance level of P<0.05. Results Following the intervention period, a significant decrease in the expression of IL-1β was observed. However, no significant difference was noted in the expression of TSP-1. Conclusion The findings suggest that combined exercises, as a non-pharmacological rehabilitation intervention, can be beneficial for individuals post-CABG by reducing systemic inflammation. [ABSTRACT FROM AUTHOR]